The RSZ BASIC programming language manual

The RSZ BASIC interactive language is described. The RSZ BASIC interpreter is resident in the Telemetry Data Processor, a system dedicated to the processing and displaying of PCM telemetry data. A series of working examples teaches the fundamentals of RSZ BASIC and shows how to construct, edit, and manage storage of programs

Why Are Radio-Galaxies Prolific Producers of Type Ia Supernovae?

An analysis of SNIa events in early type galaxies from the Cappellaro et al (1999) database provides conclusive evidence that the rate of type Ia Supernovae (SNe) in radio-loud galaxies is about 4 times higher than the rate measured in radio-quiet galaxies, i.e. SNIa-rate$(radio-loud galaxies) = 0.43^{+0.19}_{-0.14}h^2_{75}$ SNu as compared to SNIa-rate$(radio-quiet galaxies) = 0.11^{+0.06}_{-0.03}h^2_{75}$ SNu. The actual value of the enhancement is likely to be in the range $\sim 2-7$ (P$\sim 10^{-4}$). This finding puts on robust empirical grounds the results obtained by Della Valle & Panagia (2003) on the basis of a smaller sample of SNe. We analyse the possible causes of this result and conclude that the enhancement of SNIa explosion rate in radio-loud galaxies has the same origin as their being strong radio sources, but there is no causality link between the two phenomena. We argue that repeated episodes of interaction and/or mergers of early type galaxies with dwarf companions, on times-scale of about 1 Gyr, are responsible for inducing both strong radio activity observed in $\sim$14% of early type galaxies and to supply an adequate number of SNIa progenitors to the stellar population of ellipticals.Comment: 26 pages+6 figures, ApJ, in pres

The rate and the origin of type Ia supernovae in radiogalaxies

An analysis of type Ia supernova (SNIa) events in early type galaxies from Evans et al (1989) database provides strong evidence that the rate of type Ia supernovae (SNe) in radio-loud galaxies is about 6 times higher than the rate measured in radio-quiet galaxies, i.e. SNIa-rate$(radio-loud galaxies)=0.47^{+0.23}_{-0.15} h^2_{50}$ SNe per century and per 10$^{10}$L$^{B}_\odot$ (SNU) as compared to SNIa-rate(radio-quiet galaxies)\lsim 0.080 h^2_{50} SNU. The exact value of the enhancement is still rather uncertain, but is likely to be in the range $\sim 4-15$. We discuss the possible causes of this result and we conclude that that the enhancement of SNIa explosion rate in radio-loud galaxies has the same common origin as their being strong radio sources, but that there is no causality link between the two phenomena. We argue that repeated episodes of interaction and/or mergers of early type galaxies with dwarf companions are responsible for inducing both strong radio activity in $\sim$14% of early type galaxies, and the $\sim1$ Gyr old stellar population needed to supply an adequate number SNIa progenitors. Within this scenario we predict that the probability of detecting a core-collapse SN event in radio-loud elliptical galaxies amounts to about 4% of their SNIa events.Comment: 17 pages, 1 figure, accepted for publication in ApJ

Reliability and Reproducibility of Landmark Identification in Unilateral Cleft Lip and Palate Patients: Digital Lateral Vis-A-Vis CBCT-Derived 3D Cephalograms

Background: The aim of the retrospective observational study was to compare the precision of landmark identification and its reproducibility using cone beam computed tomography-derived 3D cephalograms and digital lateral cephalograms in unilateral cleft lip and palate patients. Methods: Cephalograms of thirty-one (31) North Indian children (18 boys and 13 girls) with a unilateral cleft lip and palate, who were recommended for orthodontic treatment, were selected. After a thorough analysis of peer-reviewed articles, 20 difficult-to-trace landmarks were selected, and their reliability and reproducibility were studied. These were subjected to landmark identification to evaluate interobserver variability; the coordinates for each point were traced separately by three different orthodontists (OBA, OBB, OBC). Statistical analysis was performed using descriptive and inferential statistics with paired t-tests to compare the differences measured by the two methods. Real-scale data are presented in mean ± SD. A p-value less than 0.05 was considered as significant at a 95% confidence level. Results: When comparing, the plotting of points posterior nasal spine (PNS) (p < 0.05), anterior nasal spine (ANS) (p < 0.01), upper 1 root tip (p < 0.05), lower 1 root tip (p < 0.05), malare (p < 0.05), pyriforme (p < 0.05), porion (p < 0.01), and basion (p < 0.05) was statistically significant. Conclusion: In patients with a cleft lip and palate, the interobserver identification of cephalometric landmarks was significantly more precise and reproducible with cone beam computed tomography -derived cephalograms vis-a-vis digital lateral cephalograms

Underground railroads: citizen entitlements and unauthorized mobility in the antebellum period and today

In recent years, some scholars and prominent political figures have advocated the deepening of North American integration on roughly the European Union model, including the creation of new political institutions and the free movement of workers across borders. The construction of such a North American Union, if it included even a very thin trans-state citizenship regime, could represent the most significant expansion of individual entitlements in the region since citizenship was extended to former slaves in the United States. With such a possibility as its starting point, this article explores some striking parallels between the mass, legally prohibited movement across boundaries by fugitive slaves in the pre-Civil War period, and that by current unauthorized migrants to the United States. Both were, or are, met on their journeys by historically parallel groups of would-be helpers and hinderers. Their unauthorized movements in both periods serve as important signals of incomplete entitlements or institutional protections. Most crucially, moral arguments for extending fuller entitlements to both groups are shown here to be less distinct than may be prima facie evident, reinforcing the case for expanding and deepening the regional membership regime

Suitability of databases in the Asia-Pacific for collaborative monitoring of vaccine safety

Introduction: Information regarding availability of electronic healthcare databases in the Asia-Pacific region is critical for planning vaccine safety assessments particularly, as COVID-19 vaccines are introduced. This study aimed to identify data sources in the region, potentially suitable for vaccine safety surveillance. This manuscript is endorsed by the International Society for Pharmacoepidemiology (ISPE). Methods: Nineteen countries targeted for database reporting were identified using published country lists and review articles. Surveillance capacity was assessed using two surveys: a 9-item introductory survey and a 51-item full survey. Survey questions related to database characteristics, covariate and health outcome variables, vaccine exposure characteristics, access and governance, and dataset linkage capability. Other questions collated research/regulatory applications of the data and local publications detailing database use for research. Results: Eleven databases containing vaccine-specific information were identified across 8 countries. Databases were largely national in coverage (8/11, 73%), encompassed all ages (9/11, 82%) with population size from 1.4 to 52 million persons. Vaccine exposure information varied particularly for standardized vaccine codes (5/11, 46%), brand (7/11, 64%) and manufacturer (5/11, 46%). Outcome data were integrated with vaccine data in 6 (55%) databases and available via linkage in 5 (46%) databases. Data approval processes varied, impacting on timeliness of data access. Conclusions: Variation in vaccine data availability, complexities in data access including, governance and data release approval procedures, together with requirement for data linkage for outcome information, all contribute to the challenges in building a distributed network for vaccine safety assessment in the Asia-Pacific and globally. Common data models (CDMs) may help expedite vaccine safety research across the region

Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma

In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis. PLS-DA modeling of CPMG spectra from plasma, subjected to Monte Carlo Cross Validation, allowed cancer patients to be discriminated from controls with sensitivity and specificity levels of about 90%. Relatively lower HDL and higher VLDL + LDL in the patients' plasma, together with increased lactate and pyruvate and decreased levels of glucose, citrate, formate, acetate, several amino acids (alanine, glutamine, histidine, tyrosine, valine), and methanol, could be detected. These changes were found to be present at initial disease stages and could be related to known cancer biochemical hallmarks, such as enhanced glycolysis, glutaminolysis, and gluconeogenesis, together with suppressed Krebs cycle and reduced lipid catabolism, thus supporting the hypothesis of a systemic metabolic signature for lung cancer. Despite the possible confounding influence of age, smoking habits, and other uncontrolled factors, these results indicate that NMR-based metabonomics of blood plasma can be useful as a screening tool to identify suspicious cases for subsequent, more specific radiological tests, thus contributing to improved disease management.ERDF - Competitive Factors Thematic Operational ProgrammeFCT/PTDC/ QUI/68017/2006FCOMP-01-0124-FEDER-007439SFRH/BD/ 63430/2009National UNESCO Committee - L'Oréal Medals of Honor for Women in Science 200Portuguese National NMR Network - RNRM